O'Shea Lab




The O'Shea lab is employing the help of a small DNA virus, called adenovirus, to both understand and treat cancer. Normally, cellular replication is tightly controlled. However, both DNA viruses and tumor cells sabotage such controls to drive their respective pathological propagation, albeit with one small difference: In tumor cells the key cellular players are targeted via mutations, while in infected cells viral proteins achieve the same end. Not surprisingly, many of the cellular targets are the same. The O'Shea lab is exploiting this overlap to help address three key questions.

News Highlights

W.M. Keck Award for Cracking the Nucleus

Two Microscopes Are Better Than One. Nature, 492, 293-7.

Spinning a E4dly Weave. Science, 338, 582.

Science Wonders get an artistic spin, Washington Post.

Separation of a Cell (2012). Science, 355, 529.

Viruses' Backup Plan. Nature, 466, 1054-55.
















© 2012 Salk Institute for Biological Studies
10010 North Torrey Pines Road, La Jolla, CA 92037 | 858.453.4100 | webmaster@salk.edu