O'Shea Lab


Selected Publications


Miyake-Stoner, S.J. and O’Shea, C.C. (2014) Metabolism goes viral. Cell Metab 19:549-550.

Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A.J., Long, J.A., Ellisman, M.H., Choe, S. and O'Shea, C.C. (2012) A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell 151:304-19.

Ou, H.D., May, A.P. and O’Shea, C.C. (2011) The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. Wiley Interdiscip Rev Syst Biol Med 3:48-73.

Soria, C., Estermann, F.E., Espantman, K.C. and O’Shea, C.C. (2010) Heterochromatin silencing of p53 target genes by a small viral protein. Nature 466:1076-1081.

Espantman, K.C. and O’Shea, C.C. (2010) aMAGEing new players enter the RING to promote ubiquitylation. Mol Cell 39:835-837.

Iacovides, D., O’Shea, C.C., Oses-Prieto, J., Burlingame, A. and McCormick, F. (2007) Critical role for arginine methylation in adenovirus-infected cells. J Virol 81:13209-13217.

Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B. and Evan, G.I. (2006) Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10:501-514.

O'Shea, C.C. (2005) DNA tumor viruses - the spies who lyse us. Curr Opin Genet Dev 15:18-26.

O'Shea, C.C. (2005) Viruses - seeking and destroying the tumor program. Oncogene 24:7640-7655.

O'Shea, C.C. (2005) Viruses: tools for tumor target discovery and agents for lytic cancer therapies - an introduction. Oncogene 24:7636-7639.

O'Shea, C.C., Choi, S., McCormick, F. and Stokoe, D. (2005) Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle 4:883-888.

O'Shea, C.C. and Fried, M. (2005) Modulation of the ARF-p53 pathway by the small DNA tumor viruses. Cell Cycle 4:449-452.

O'Shea, C.C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F. and Stokoe, D. (2005) Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J 24:1211-1221.

O'Shea, C.C., Soria, C., Bagus, B. and McCormick, F. (2005) Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 8:61-74. [Cover Article]

O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D. and McCormick, F. (2004) Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 6:611-623.  



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