O'Shea Lab


American Society for Cell Biology ASCB TV

Produced by WebsEdge/Health
December 2014

Cold viruses point the way to new cancer therapies

October 16, 2012

Adenovirus, a type of cold virus, has developed molecular tools—proteins—that allow it to hijack a cell's molecular machinery, including large cellular machines involved in growth, replication and cancer suppression. The Salk scientists identified the construction of these molecular weapons and found that they bind together into long chains (polymers) to form a three-dimensional web inside cells that traps and overpowers cellular sentries involved in growth and cancer suppression. The findings, published October 11 in Cell, suggest a new avenue for developing cancer therapies by mimicking the strategies employed by the viruses. Read more>>

Cathedrals of Culture

Salk Institute, La Jolla, CA
Film by Robert Redford
June 5, 2014 (published)

TWiV 291: Ft. Collins abuzz with virologists

33rd annual meeting of the American Society for Virology at Colorado State
University in Ft. Collins, Colorado
Featuring Clodagh O'Shea
Hosted by Vincent Racaniello
June 5, 2014 (published)

Use the common cold virus to target and disrupt cancer cells?

August 25, 2010

A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of Nature. Read more>>


Viruses and Cancer - Clodagh O’Shea, Salk Institute from Kavli Frontiers of Science on Vimeo.







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